Custom Peptides
Cayman Chemical TIrapazamIn 10mg
A tyrosine kinase inhibitor inhibits IGF-1R and FGFR2 (IC50s 1.6 and 50s 5 3.1 2 and 6.1 nM respectively) inhibits proliferation of CML and ALL cell lines (IC50s 100 nM)
Cayman Chemical SphngosInd14 1 10mg
A potent inhibitor of Aurora A kinase (IC50 42 nM) selective for Aurora A over BMX BTK IGF-1R c-Src TRKB SYK and EGFR (IC50s 386 3550 591 1980 2510 887 and 10000 nM respectively)
Cayman Chemical 1 2DIoleoyl3dImethylamonI 10mg
An agonist of a1- and a2-ARs (Kds 6 320 and 390 nM for a1A- a1B- and a1D-ARs respectively Ki 15 nM for a2-AR) acts as an agonist of 5-HT1 receptors (Kds 4.68 25.7 5.01 nM for 5-HT1A 5-HT1B and 5-HT1D respectively) increases intracellular calcium levels in CHO cells transfected with the a1A-AR (EC50 40.7 nM) acts as a partial agonist of the a2-AR in perfused rat heart (IC50 63 nM and EC50 13.5 nM for norepinephrine release) acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin and clonidine respectively (Kds 110 and 257 nM respectively) inhibits forskolin-stimulated adenylate cyclase activity (EC50s 18.6 24.0 and 44.7 nM in tissues expressing high levels of 5-HT1A 5-HT1B and 5-HT1D receptors respectively) and accumulation of inositol phosphates (EC50 269 nM in pig choroid plexus preparations which highly express 5-HT1C receptors) decreases nasal pressure in dogs by 6.9 when used at a dose of 0.2 g/kg
Cayman Chemical CryptochlorogenIc AcId 10mg
A Bcl-6 inhibitor (Ki 147 UM) selective for Bcl-6 over Kaiso HIC1 and PLZF at 50 UM cytotoxic against SU-DLH-6 SU-DLH-4 Farage OCI-LY7 OCI-LY1 and OCI-LY10 DLBCL cells (GI50s 0.024-0.936 mM) increases expression of ATR TP53 CD69 p21 and CD44 in SU-DLH-6 and SU-DHL-4 cells at 50 UM reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models at 50 mg/kg
Cayman Chemical 3-keto SphngnInd18 0h 10mg
A RARa antagonist increases chaperone-mediated autophagy in an RARa-dependent manner increases LAMP-2A expression and inhibits paraquat-induced decreases in cell viability in mouse fibroblasts at 20 M selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s 10 and 1000 M respectively)
Cayman Chemical 2HChoArgtrIfluoroacetAT 10mg
A metabolite of pentachlorophenol cytotoxic to RTL-W1 rainbow trout liver cells (EC50 1.55 M in a neutral red assay) increases production of ROS inhibits apoptosis and induces loss of the mitochondrial membrane potential and necrosis in splenocytes induces GSH depletion in mouse liver
Cayman Chemical 27hydroxy HeptacosNIc ACD 10mg
An adenosine A2B receptor antagonist (Ki 53.4 nM) selective for A2B over A1 and A2A receptors which have Ki values of 2200 and 24000 nM respectively selective for A2B over the A3 receptor which is inhibited only 14 at a concentration of 10 UM pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical nglca ctodoa nc Mamsn 10mg
A FAK inhibitor selective for FAK over 261 kinases inhibits FAK autophosphorylation at Y397 in OVCAR8 ovarian U87MG glioblastoma and A549 lung cancer cell lines (IC50s 15 8.5 and 12 nM respectively) induces apoptosis decreases viability (IC50 25 UM) and inhibits colony formation in L3.6P1 cells leads to lower tumor weight and fewer metastases in an orthotopic mouse model of uterine cancer at 75 mg/kg per day
Cayman Chemical 1 2DIpalmItoyl3Pentadecno 10mg
An internal standard for the quantification of N -(1-carboxymethyl)-L-lysine by GC- or LC-MS
Cayman Chemical 1 2DIarachIdoylracglycRol 10mg
A CB2 agonist (Ki 40 3 nM) selectively activates CB2 over CB1 in a GTPYS binding assay (EC50s 20 1 and 100000 nM respectively) reduces differences in hind paw weight bearing between MIA- and saline-injected knees in a rat model of knee joint-related chronic pain induced by MIA at 0 1 mg/kg dose-dependently reduces paclitaxel-induced mechanical and cold allodynia in mice and prevents development of morphine tolerance at 3 mg/kg per day for 12 days reduces paclitaxel-induced allodynia in morphine-tolerant mice
Cayman Chemical CAY10740hydrochlorIde 10mg
A DGAT-1 inhibitor (IC50 15 nM) selective for DGAT-1 over DGAT-2 and ACAT-1 (IC50s 10 and 12 M respectively) inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 4 nM) reduces plasma triacylglycerol levels the ratio of triacylglycerolsdiacylglycerols and body weight in a mouse model of diet-induced obesity at 20 mg/kg
Cayman Chemical 1 2DIpalmItoyl3Decnoylra 10mg
An analytical reference standard categorized as a synthetic cannabinoid intended for research and forensic applications
Cayman Chemical 1 2DIlInoleoyl3Stearoylra 10mg
A monoacylglycerol containing oleic acid at the sn-1 position enhances diffusion of cyclosporin A from the donor compartment of a Franz diffusion cell into the stratum corneum epidermis and dermis of porcine ear skin as well as through the skin to the receptor compartment in a formulation with cyclosporin A in propylene glycol mixed micellar systems with bile salts increases the Papp and absorption rate of amphotericin B in perfused rat intestine in vivo
Cayman Chemical 1 2DIpalmItoyl3LInoleoylr 10mg
A monoacylglycerol containing oleic acid at the sn-1 position enhances diffusion of cyclosporin A from the donor compartment of a Franz diffusion cell into the stratum corneum epidermis and dermis of porcine ear skin as well as through the skin to the receptor compartment in a formulation with cyclosporin A in propylene glycol mixed micellar systems with bile salts increases the Papp and absorption rate of amphotericin B in perfused rat intestine in vivo
Cayman Chemical 8-NItrotryptnthrIn 10mg
A fungal metabolite reduces AB aggregate-induced neurotoxicity in PC12 cells (EC50 112 6 M) induces tremors in mice at 30 mg/kg