Custom Peptides
Cayman Chemical SImurosertIb 10mg
An inhibitor of Cdc7 kinase (IC50 = 0.26 nM); selective for Cdc7 over Cdk2 and ROCK1 (IC50s = 6,300 and 430 nM, respectively); inhibits phosphorylation of MCM2 in HeLa cells (IC50 = 17 nM); reduces proliferation of COLO 205 cells (EC50 = 81 nM); inhibits the growth of a wide variety of cancer cells (GI50s = 30.2->10,000 nM); reduces intratumor levels of phosphorylated MCM2 in COLO 205 and SW948 mouse xenograft models at 80 mg/kg and reduces tumor growth in the same models when administered at doses of 40 or 60 mg/kg twice per day
Cayman Chemical 25C-NBOHhydrochlorIde 10mg
A derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine; a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively); intended for forensic and research applications
Cayman Chemical Ac-Gly-Lys-OMeacetate 10mg
A synthetic peptide urokinase substrate; has been used to characterize the effects of small molecule inhibitors and metal ions on urokinase activity in cell-free assays
Cayman Chemical nrvonyl EthnolamIde 10mg
A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids
Cayman Chemical 4methoxyaPyrroldInopentIo 10mg
Shares structural features with the stimulant α-PVP, whose mechanism of action is unknown but is believed to act similarly to the designer drug MDPV
Cayman Chemical XE 991hydrochlorIde 10mg
A blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM); shows good in vivo potency and duration of action
Cayman Chemical Latnoprosten Bunod 10mg
A nitric oxide-donating FP receptor agonist; induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM, respectively); topical administration reduces IOP in canine and rabbit models of glaucoma at 0.036%; decreases IOP in a cynomolgus monkey model of laser-induced ocular hypertension
Cayman Chemical ElaIdIc AcId-d17 10mg
An internal standard for the quantification of elaidic acid by GC- or LC-MS
Cayman Chemical Lacto-N-tetraose 10mg
An oligosaccharide; promotes the growth of the bacterium B. longum and B. breve; levels are increased in breast milk from mothers of rotavirus-positive neonates with gastrointestinal symptoms and are positively correlated with levels of Enterobacter and Klebsiella in maternal milk and infant stool
Cayman Chemical Rubmaln 10mg
A naphthohydroquinone with diverse biological activities; inhibits the growth of E. coli and S. aureus in a disc assay at 100 μg per disc; scavenges DPPH free radicals in a cell-free assay (IC50 = 0.7 μM); inhibits ACAT1 and ACAT2 (IC50s = 80 and 22 μM, respectively) and cholesterol ester synthesis (IC50 = 18 μM) in murine macrophages; increases BMP2-induced osteoblastic differentiation of C2C12 mesenchymal progenitor cells; enhances skeletal development in zebrafish larvae; inhibits TNF-α-induced NF-κB reporter gene expression and nuclear translocation of p65 and potentiates TNF-α-induced apoptosis in HeLa cells; reduces tumor growth in a HeLa mouse xenograft model at 25 and 75 mg/kg
Cayman Chemical 1 1EthylIdenbIs Ltrypto 10mg
A potential impurity found in commercial preparations of L-tryptophan; increases the proliferation of EoL-3 eosinophilic leukemia cells, release of eosinophil cationic protein from isolated human peripheral blood eosinophils, and IL-5 production in isolated human T cells; induces fascia thickening and increases mast cell infiltration, inflammation, and fibrosis in superficial adipose and panniculus carnosus tissues in a mouse model of eosinophilia-myalgia syndrome at 40 UG/kg
Cayman Chemical 1MyrIstyl2hydroxysnglyce 10mg
An LPA derivative and agonist of LPA1 and LPA2; increases calcium mobilization in a reporter assay using HEL 92.1.7 cells (EC50 = 37 nM)
Cayman Chemical TIn MSoporphyrIn IXCLOrId 10mg
A potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM); inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time; blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia