Custom Peptides
Cayman Chemical ACTH7-38humntrIfluor 10mg
A peptide fragment of ACTH and an antagonist of MC2R; inhibits ACTH-induced corticosterone production in isolated rat adrenal cells at 0.455 or 4.55 µM; inhibits ACE1 (IC50 = 750 nM for the dog enzyme); inhibits basal cAMP secretion by isolated rat inner adrenocortical cells at 1 µM; induces hypotension in normotensive dogs (ED50 = 0.109 nmol/kg)
Cayman Chemical Scutlaa bacalns Ngltn 10mg
A flavonoid with diverse biological activities; inhibits biofilm formation by S. aureus, B. subtilis, P. aeruginosa, and E. coli at 32 UG/ml; rinduces cytotoxicity in SW460 and DLD-1 cancer cells (IC50s = 29.41 and 30.93 µM, respectively) but not HT-29 or HepG2 cancer cells (IC50s = >40 µM for both); decreases LPS-induced NO production and secreted TNF-α and IL-1β levels in J774A.1 macrophages at 0.01 µM; alone and in combination with NGF increases neurite outgrowths, levels of GAP43, and decreases serum deprivation-induced death in PC12 cells at 10 µM
Cayman Chemical GC7sulfate 10mg
A deoxyhypusine synthase inhibitor (Ki = 9.7 nM); inhibits the production of hypusine in CHO cells at 1 µM; inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells at 20 µM; reduces tumor growth in a Melan-a Tm5 murine melanoma model at 0.9 mg/kg
Cayman Chemical CefoselIsulfate 10mg
A cephalosporin antibiotic; active against clinical isolates of extended-spectrum β-lactamase-producing E. coli, K. pneumoniae, and P. mirabilis, as well as C. freundii, E. aerogenes, E. cloacae, S. marcescens, and P. vulgaris; protective against lethality in mouse models of systemic infection induced by various bacteria (ED50s = ≤0.025-1.56 mg/kg); reduces the number of renal CFUs in a mouse model of S. epidermidis-induced ascending pyelonephritis at 50 mg/kg
Cayman Chemical HIstatIn 3trIfluoroacetAT 10mg
An antimicrobial peptide; active against C. albicans (LC50 = 9.2 µM); induces actin polymerization in a cell-free assay at 12 µM
Cayman Chemical VIlnteroltrIphenylacetate 10mg
A β2-AR agonist; selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively); inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips; inhibits histamine-induced bronchospasms in guinea pigs when administered via nebulization (EC50 = 30 µM)
Cayman Chemical NformylNleLeuPheNleTyr 10mg
A chemotactic peptide; binds to the FPR (Kd = 2.2 nM); has been conjugated to various fluorophores to monitor FPR internalization
Cayman Chemical 2C-TFMhydrochlorIde 10mg
A 2C compound with a para-trifluoromethyl substitution. It is a potent agonist of the 5-HT receptor subtypes 5-HT2A and 5-HT2C (Kaff = 165 and 32 nM); intended for forensic and research purposes
Cayman Chemical N6-CyclopentyladenosIn 10mg
A selective agonist at A1R (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively)
Cayman Chemical MDL 12330AhydrochlorIde 10mg
An adenylyl cyclase inhibitor that can also inhibit cAMP and cGMP phosphodiesterases and block slow extracellular and store-operated Ca2+ entry into cells; blocks voltage-dependent K+ channels, extends action potential duration, and enhances insulin secretion in pancreatic β-cells
Cayman Chemical N-AcetylserotonIn 10mg
An analytical reference standard categorized as a tryptamine; a precursor in the synthesis of melatonin; intended for analytical forensic applications
Cayman Chemical 2 3MehylendIoxy PyrovalRo 10mg
A potential psychoactive designer drug structurally related to 3,4-MDPV; intended for forensic purposes
Cayman Chemical DIhydrokaInIc AcId 10mg
An inhibitor of EAAT2 (Ki = 23 µM); selective for EAAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both); reduces depressive-like behavior in rats in the forced swim test at 5 nmol infused into the infralimbic cortex; induces anhedonia-like behavior in rats in a sucrose intake test at 6.25 nmol infused into the PFC; impairs memory acquisition, consolidation, and retrieval in mice in the novel object recognition test
Cayman Chemical 4-fluoro BZPhydrochlorIde 10mg
A substituted benzylpiperazine with a potential for abuse; intended for forensic and research applications